Molphologic study of platelet have been done by many authors for the past years. they investigated that the heterogeneity o: platelet size was shown even in normal person and various hematologic disorder. In the past the platelet size was not utilized in clinical medicine because of its technical difficulties of measuring.
Recently, an automated blood cell counter, Coulter Counter Model Splus Ⅱ, was introduced and platelet size could be easily gained, which expressed by mean platelet volume (MPV).
Therefore, this study was planned to evaluate the clinical significance of MPV in health person and various hematologic disease.
The following results were obtained:
1. In healthy person, MPV was decreased along with increasing the platelet number.
2. In thrombocytopenic patients, MPV was decreased more than normal.
3. In various hematologic disease, MPV was decreased in acute leukemia, marrow failure and aplastic anemia, normal in iron deficiency anemia, increased in reactive marrow, MPV was varied by plaielet number in various hematologic disease. This disclosed that MPV was related with marrow function and production of megakaryocytes.
From these results, MPV could he used as a valuable parameter in the evaluation of platelet together with measuring the platelet number.
Particular relation-ship between MPV and various hematologic disease were not observed. W^c should be more study for MPV.
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